Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography.
نویسندگان
چکیده
Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi(3+) exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CXnC, CXnH and HXnH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 92 شماره
صفحات -
تاریخ انتشار 2015